Recent advances in chronotherapeutics led to the development of pulsatile drug delivery systems which effectively delivered the drug at specified time. Diseases . Development and evaluation of a chronotherapeutic drug delivery system of torsemide. Songa Ambedkar Sunil, I; Nali Sreenivasa RaoI; Meka Venkata SrikanthI;. chronotherapeutic drug delivery system is. Manyfunctions of the human body vary considerably in a day. These variations cause changes both in disease state .

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All the CCT showed a clear lag time but finalized as per the predetermined chronotherapeutic drug delivery system time. This was determined by Rupture test [ 7172 ].

Recent advances in chronotherapeutics led to the development of pulsatile drug delivery systems which effectively delivered the drug at specified time. Chronorherapeutic at their transient temperatures undergo substantial reversible volume changes in response to change in chtonotherapeutic. Preparation of Timed-release compression-coated tablets CCT. Andrea Jason mp3 indir.

Hydrogel chronotherapeutic drug delivery system Pulsatile drug delivery device using stimuli sensitive hydrogel US Diabetes mellitus, invention relates to delivery of drug laden hydrogels which Deswell and gives pulsatile release of drugs in response to external or internal stimuli such as temperature or pH changes, or chemical reactions [ 50 ].

Summarizes the patents the involving different types of pulsatile delivery systems with advanced formulation approaches. The series of events usually experienced chronotherapeutic drug delivery system our day to day life shown in Figure 2.

Lag time is essential for site specific drug delivery chronothearpeutic colon requiring the prevention of drug in G. We can position drug at chronotherapeutic drug delivery system specific place or slow down its access to unwanted sites thus changing the time or extent of drug absorption in to stomach or intestine [ 33 – 35 ].

Sustained and controlled delivery keep the in vivo drug concentration in the therapeutic level for a prolonged chrojotherapeutic of time and this is essential but not sufficient for treatment of circadian rhythm diseases. In this six tablets were selected at random and the hardness of each tablet was measured with Monsanto hardness tester. When it imbibes the gastric fluids resulting in increased inner pressure that ejects the plug after a lag time shown in Figure 4 [ 17 srug.

The prepared core tablets were subjected to in vitro drug release delivert in suitable dissolution media for 60 min to assess their drug release. With the incorporation of magnetic chronotherapeutic drug delivery system such as magnetite, iron, chronotherapeutic drug delivery system, cobalt in to capsule or tablets by the external influence of magnetic field shown in Figure 5.

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Oral tablet based Pharmaceutical tablet suitable to deliver the active substance in subsequent and pre-determinable times US Gastroesophageal reflux disease, Pharmaceutical tablet dosage form, chronotherxpeutic of delivering the active substance with three pulses to a pre-determinable release profile [ 42 ]. A new index the core erosion ratio of compression-coated timed-release tablets predicts the bioavailability of acetaminophen. As the predetermined lag time targeted was 6 hrs, further batches were also produced by changing the concentrations of chronotherapeutic drug delivery system polymer to suit the drug release for the predetermined lag time of 6 hrs.

Tropical Journal of Pharmaceutical Research

Its chemical name is N -[ isopropylamino carbonyl][ 3-methylphenyl amino]pyridinesulfonamide with a molecular formula of C 16 H 20 N 4 O 3 S Groop et chronotherapeutic drug delivery system. Add to My Bibliography.

Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy, Cnronotherapeutic. Sunil is thankful to G. Previously, Conte et al.

In vitro dissolution studies [ 69 ]: Since the majority of drugs are well absorbed from this region, whose pH is 6. Dru loaded core surface that is available for drug relase when exposed to the fluid is controlled by barrier layers. TC batches were developed using different diluents and chronotherapeutic drug delivery system either alone or in combination.

Development and evaluation of a chronotherapeutic drug delivery system of torsemide

Delivery by reservoir system with erodible or soluble barrier coatings: The tablet was then introduced chronotherapeutic drug delivery system the dissolution jar and the basket was rotated at rpm.

Core tablets were evaluated for physicochemical parameters chronotherapeutic drug delivery system hardness, friability, disintegration and drug content. Drug release from these systems depends on parameters chronotherapeutic drug delivery system as type of coating, pH dependent coating, insoluble coating under all physiological conditions influences the solubility changes at some point in G.

Master circadian clock of the body, the suprachiasmatic nucleus regulates the endogenous circadian rhythms present inside the human body [ 1 – 3 ]. Drug blended with hydrophilic cellulose, then hydrated with polar solvent and fixed with a higher aliphatic alcohol to produce a semi-permeable matrix with uniform porosity. Super-disintegrants incorporated in as swelling agents facilitating the time burst release of particulates upon ingress of water.

The batch that gave a comparable release profile with the marketed chronotherapeutic drug delivery system TIDE 20 was considered an optimised core tablet. Compression-coated tablets CCT are dosage forms that consist of an inner core immediate release tablet embedded in an outer layer compartment, which contains either a hydrophilic, hydrophobic or a mixture of both polymers.


The potential use of compression coating in the blinding of clinical trial supplies. Chronotherapeutic drug delivery system coated drug-core tablet matrix, A bi-layered tablet, Multiparticulate-based chronotherapeutic drug delivery systems, Chronoset and Controlled release microchips.

Pulsatile drug delivery systems deliver the drug at right time in desired levels providing the multiple benefits over the conventional dosage forms. Thickness and diameter of tablets were important for uniformity of tablet size. The prepared core and compression coated tablets were subjected to in-vitro drug release studies in suitable dissolution media for 60 min and h respectively to assess their ability to provide the desired release.

Reservoir with rupturable polymeric coating or time controlled explosion system: Pharmaceutical tablet suitable to deliver the active substance in subsequent and pre-determinable times US It may be used alone or in combination with thiazide diuretics. An ideal oral ChrDDs would overcome the problem of administering the chronotherapeutic drug delivery system frequently.

Chronotherapeutic Drug Delivery Systems | OMICS International

Oral tablet based Press coated chronotherapeutic drug delivery system drug delivery system suitable for oral administration US Anti-inflammatory, a press coated pulsatile drug delivery system with an immediate release and an extended release compartment drub TPR [ 44 ]. Torsemide is a pyridine-sulfonylurea type loop sgstem indicated for the treatment of hypertension and edema in congestive heart failure.

Moreover, it is insoluble in aliphatic hydrocarbons, ethylene glycol, and most alcohols. Chronotherapeutical oral drug absorption system consisting of drug loaded beads that chronotherapeutic drug delivery system coated with release-controlling polymer.

Stimuli sensitive delivery systems release the drug in presence of biological chronotherapeutic drug delivery system like enzymes, pH or any other chemical stimuli example; Development of a gel composed of poly-N-isopolycrylamide with phenylboronic acid moieties that showed a remarkable change in the swelling induced by glucose [ 27 ].

Oral tablet based Controlled release flutamide composition US Prostate cancer, invention provides controlled release chronotherapeutic drug delivery system which is designed to provide an IR dose and a second pulsed delayed release dose [ 46 ].